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Cat.No. Product Name / Introduction Added
CS-3336 LY2857785 August 2014
LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.
 
CS-3335 ARN2966 August 2014
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.
 
CS-3334 Andrographolide August 2014
Andrographolide(Andrographis) is an irreversible antagonist of NF-κB and prevents in vitro T cell activation; displays antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties.
 
CS-3333 6-O-alpha-Maltosyl-beta-cyclodextrin August 2014
6-O-α-maltosyl-β cyclodextrin (Mal-βCD) is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol and is much less cytotoxic to human erythrocytes and Caco-2 cells; a cyclodextrin derivative.
 
CS-3332 Ro-61-8048 August 2014
Ro 61-8048 is a potent and selective inhibitors of kynurenine hydroxylase with IC50 of 37 nM.
 
CS-3331 PKC412 August 2014
PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor; inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR.
 
CS-3330 FH1 August 2014
FH1(BRDK4477) is a small molecule that can enhance the functions of cultured hepatocytes.
 
CS-3329 Cerdulatinib August 2014
Cerdulatinib(PRT-062070; PRT2070) is an novel oral dual Syk/JAK inhibitor.
 
CS-3328 GSK-J1-lithium-salt August 2014
GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro).
 
CS-3327 ATN-161 August 2014
ATN-161 (Ac-PHSCN-NH2) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.
 
CS-3327 ATN-161 August 2014
ATN-161 (Ac-PHSCN-NH2) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.
 
CS-3326 GSK2110183 August 2014
GSK2110183 is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.
 
CS-3325 c-di-AMP August 2014
Cyclic-di-AMP (c-di-AMP) is a second messenger molecule produced in bacteria but not in mammals; can induce a strong immune response in vitro and in vivo.
 
CS-3324 GSK2194069 August 2014
GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.
 
CS-3323 SB269652 August 2014
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
 
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Recommended Products
CS-0757 SB-705498
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.
CS-0766 Aripiprazole
Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.
CS-0765 CYT387 sulfate salt
CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively.
CS-0645 Rimonabant
Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.
CS-0494 XAV-939
XAV939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
CS-0264 DAPT
DAPT is inhibitor of γ-secretase.
CS-0361 Boceprevir
Boceprevir(EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
CS-0592 YM-201636
YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).
CS-0613 Tideglusib
Tideglusib(NP-031112) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM.
CS-0625 Avosentan
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
CS-0609 SCH 527123
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CS-0612 T 705
T 705(Favipiravir) is a RNA-directed RNA polymerase NS5B inhibitor.
CS-0614 Suvorexant
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
CS-0627 MEK162
MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.
CS-0608 BMS-754807
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.

 
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