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Cat.No. Product Name / Introduction Added
CS-3479 E7449 November 2014
E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2; enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors.
CS-3478 Lesinurad-sodium November 2014
Lesinurad sodium (RDEA594 sodium) is an once-daily inhibitor of URAT1; URAT1 is a transporter in the kidney that regulates uric acid excretion from the body.
CS-3477 SCH-1473759-hydrochloride November 2014
SCH 1473759 Hcl is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
CS-3476 CBB1003 November 2014
CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.
CS-3475 BIBF-1120-esylate November 2014
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.
CS-3474 NKP-1339 November 2014
NKP-1339(IT-139) is a ruthenium(iii) coordination anticancer compound based on target to transferrin.
CS-3473 IRAK-inhibitor-4-trans November 2014
IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4,which is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
CS-3471 Verdinexor November 2014
Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus replication in vitro and in vivo.
CS-3470 Emapunil November 2014
Emapunil(AC-5216;XBD-173) is a translocator protein [TSPO (18 kDa)] ligand.
CS-3469 Vinflunine-Tartrate November 2014
Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
CS-3468 SSR128129E-free-acid November 2014
SSR128129E free acid is a multi-FGFR blocker with allosteric properties; inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding.
CS-3467 SSR128129E November 2014
SSR128129E is a multi-FGFR blocker with allosteric properties; inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding.
CS-3466 LB-100 November 2014
LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.
CS-3465 Y15 November 2014
Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.
CS-3463 ZLN024-hydrochloride November 2014
ZLN024 Hcl is a novel AMPK allosteric activator; activated α1β1γ1 and α2β1γ1 by around 2–2.
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CS-0757 SB-705498
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.
CS-0766 Aripiprazole
Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.
CS-0765 CYT387 sulfate salt
CYT387 sulfate(momelotinib) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3.
CS-0645 Rimonabant
Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.
CS-0494 XAV-939
XAV939 is a small molecule and selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
CS-0264 DAPT
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo.
CS-0361 Boceprevir
Boceprevir(EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
CS-0592 YM-201636
YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α.
CS-0613 Tideglusib
Tideglusib(NP-031112) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM.
CS-0625 Avosentan
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
CS-0609 SCH 527123
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CS-0612 T 705
T 705 (Favipiravir) is an experimental anti-viral drug with activity against many RNA viruses; RNA-directed RNA polymerase NS5B inhibitor.
CS-0614 Suvorexant
Suvorexant (MK-4305) is a potent dual OX receptor antagonist with Ki of 0.
CS-0627 MEK162
MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM.
CS-0608 BMS-754807
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.

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