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Home   »   Product Pathways  »  Infection  »  Kanamycin sulfate

Products are for research use only. Not for human use. We do not sell to patients.


CS-1140 Kanamycin-sulfate


(Kanamycin A monosulfate)
Structure Price and Availability of    Kanamycin-sulfate
United States
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Kanamycin-sulfate  M.Wt: 582.58
Kanamycin-sulfate  Formula: C18H38N4O15S
Kanamycin-sulfate  Solubility: Water > 10 mg/ml
Kanamycin-sulfate  Purity: >98%
Kanamycin-sulfate  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 25389-94-0

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Kanamycin (also known as kanamycin A) is an aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms. Inhibitor of protein biosynthesis that acts on the 30S ribosome, causing misreading of the genetic code. Kanamycin may cause renal damage and ototoxicity.

1 . Kanamycin

2 . Firth EC, Klein WR, Nouws JF, Wensing T. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62.
Abstract
Single doses of sodium ampicillin (10 mg/kg) and kanamycin sulfate (5 mg/kg) were administered intramuscularly (i.m.) separately, and then together, to five pony mares. The plasma antibiotic concentration-time curves were constructed. The pharmacokinetic parameters of the antibiotics given separately were not altered by concurrent administration. Four of the five pony mares were then given the i.m. kanamycin/ampicillin combination 4 h after acute synovitis and fever had been induced by injection of lipopolysaccharide into the left intercarpal joint. The plasma concentration-time curves and the synovial concentration-time curves of inflamed and normal joints were constructed. The Cmax of ampicillin in the lipopolysaccharide experiment was significantly higher than in the other experiments. The antibiotics entered the synovial fluid of the inflamed joints more quickly and attained higher concentrations than in the uninflamed joints. The ampicillin concentration exceeded 5 micrograms/ml in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeded 2 micrograms/ml for 7 h.

3 . Guo WS, Zhe J, Zhao WW, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493.
Abstract
Effect of kanamycin sulfate and gentamicin on growth of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus casei, Lactobacillus rhamnosus and Lactobacillus bulgaricus was studied by measuring the optical density at 600nm and pH using MRS broth as the control. The addition of kanamycin sulfate (%, w/v) was 0.0025, 0.005, 0.0075 and 0.01 and the addition of gentamicin(U/ml) was 48, 72, 144, 192 and 240. Results were as follows: addition of kanamycin sulfate at the concentration above 0.0025% has a significant inhibition on the growth of B. bifidum and has no influence on the other four probiotics at incubation12h or 24h. The optimum selective concentration of kanamycin sulfate in MRS media was 0.005% for selective enumeration of B.bifidum. Addition of gentamicin at the concentration above 240U/ml has a significant inhibition on the growth of L. bulgaricus at incubation 24h. Addition of neomycin sulfate in MRS can use to realize selective enumeration of L. bulgaricus in yogurt.

4 . Mohamed el SW, Mohamed el NA, Yousif Bel D, Fahal AH. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4.
Abstract
A 60-year-old male farmer presented with tongue swelling of 1-month duration. Local oral clinical examinations showed a painless firm mass in the anterolateral aspect of the anterior third of the tongue. Fine needle aspiration for cytology confirmed the diagnosis of tongue actinomycetoma due to Actinomadura madurae. The patient underwent wide local excision under general anesthesia and had an uneventful postoperative recovery. He was started on amikacin sulfate 15 mg/kg daily and cotrimoxazole 15 mg/kg twice per day for 6 months. The lesion healed completely, with no evidence of recurrence at 6-month follow-up. The route of infection in this patient is unclear; however, direct traumatic inoculation is the most likely route. To the authors' knowledge, this is the first report of tongue mycetoma in the medical literature.

5 . Fan GR, Yin ZD, Sun Y, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. pii: S0006-8993(13)00068-1.
Abstract
The time course of aminoglycoside neurotoxic effect on cochlear nucleus is still obscure. We examined dynamic pathological changes of dorsal cochlear nucleus (DCN) and investigated whether apoptosis or autophagy was upregulated in the neurotoxic course of kanamycin on DCN after kanamycin treatment. Rats were treated with kanamycin sulfate/kg/day at dose of 500mg by subcutaneous injection for 10 days. Dynamic pathological changes, neuron density and neuron apoptosis of the DCN were examined at 1, 7, 14, 28, 56, 70 and 140 days after kanamycin treatment. The expression of JNK1, DAPK2, Bcl-2, p-Bcl-2, Caspase-3, LC3B and Beclin-1 were also detected. Under transmission electron microscopy, the mitochondrial swelling and focal vacuoles as well as endoplasmic reticulum dilation were progressively aggravated from 1 day to 14 days, and gradually recovered from 28 days to 140 days. Meanwhile, both autophagosomes and autolysosomes were increased from 1 day to 56 days. Only few neurons were positive to the TUNEL staining. Moreover, neither the expressions of caspase-3 and DAPK2 nor neurons density of DCN changed significantly. LC3-II was drastically increased at 7 days. Beclin-1 was upgraded at 1 and 7 days. P-Bcl-2 increased at 1, 7, 14 and 28 days. JNK1 increased at 7 days, and Bcl-2 was downgraded at 140 days. LC3-B positive neurons were increased at 1, 7 and 14 days. These data demonstrated that the neurons damage of the DCN caused by kanamycin was reversible and autophagy was upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway.

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