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Inhibitors by pathways
Cell Cycle/DNA Damage
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treatment of obesity
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SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.
Aripiprazole is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression.
CYT387 sulfate salt
CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively.
Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.
XAV939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4nM for the inhibition of TNKS1 and TNKS2, respectively.
DAPT is inhibitor of γ-secretase.
Boceprevir(EBP 520; SCH 503034 ) is useful for Anti HCV.
YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).
Tideglusib is useful for Alzheimer's Disease .
Avosentan(Ro 67-0565; SPP-301) is an Endothelin Antagonist.
Sch527123 is a potent, selective antagonist of the human CXCR1 and CXCR2 receptors.
T 705(Favipiravir) is a RNA-directed RNA polymerase NS5B inhibitor.
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
MEK162(ARRY-162; ARRY-438162) is an oral, highly selective MEK inhibitor.
BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity.
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