Pexidartinib
CAS No. : 1029044-16-3

Pexidartinib
Cat. No. : CS-4256
M. Wt. : 417.81
chem_1Easy Returns chem_3  Custom Services chem_2Research Use Only
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5mg In-stock $50.0
10mg In-stock $70.0
50mg In-stock $150.0
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200mg In-stock $360.0
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  • Data Sheet

  • Introduction

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Name: Pexidartinib; PLX-3397
Cat. No. : CS-4256
CAS No. : 1029044-16-3
Formula: C20H15ClF3N5
M. Wt. : 417.81
Solubility: DMSO: ≥ 30 mg/mL
Download Informations Download Data Sheet

Activity:

Pexidartinib is a receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3, with potential antineoplastic activity, with IC50 of 28 and 16 nM for Fms and Kit, respectively. IC50 & Target: IC50: 28 nM (c-Fms), 16 nM (c-Kit) In Vivo: Pexidartinib is a potent drug for treatment of cancer and used for Phase III TGCT clinical trial[1].

Protocol:

References:

Gelhorn HL, et al. Patient-reported Symptoms of Tenosynovial Giant Cell Tumors. Clin Ther. 2016 Apr;38(4):778-93.

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