P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 exerted an antidepressant-like effect in wild-type littermates than P7C3. display increased activity and an improved toxicity profile compared to P7C3. P7C3 is a NAMPT activator.
In vivo: The P7C3-A20 exhibited antidepressant efficacy both in stressed Ghsr-null mice and in their more resilient, stressed wild-type littermates. [1] P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI. ( Traumatic brain injury ) . The reference for G93A-SOD1 mice is 20 mg/kg/d. [2]
Protocol:
References:
Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury.
J Neurotrauma. 2014 Mar 1;31(5):476-86.
Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20(4):500-8.
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