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CAS No. : 1416258-16-6
|Size||Stock||Price||Quantity||Add to Cart||Quotation Online|
|5mg||In-stock||USD 420.0 420.0|
|10mg||In-stock||USD 600.0 600.0|
|50mg||In-stock||USD 1800.0 1800.0|
|100mg||In-stock||USD 2520.0 2520.0|
|Cat. No. :||CS-3511|
|CAS No. :||1416258-16-6|
|M. Wt. :||405.49|
|Solubility:||10 mM in DMSO|
(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells)  Target: integrase inhibitor in vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells .
Protocol:Antiviral activity assay: E9 MEF cells (5 x 103) seeded in wells of a 96-well plate were infected in quadruplicate with HIV-Luc (5 x 105 RT-cpm) in the presence of serial dilutions of BI-D or dimethyl sulfoxide solvent control to determine half-maximal inhibitory concentration (IC50) values of the drug. Luciferase activity was determined 2 d post-infection.
Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):11518-30.
Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.
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