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CAS No. : 2115701-93-2
|Size||Stock||Price||Quantity||Add to Cart||Quotation Online|
|5mg||In-stock||USD 140.0 140.0|
|10mg||In-stock||USD 220.0 220.0|
|25mg||In-stock||USD 420.0 420.0|
|50mg||In-stock||USD 710.0 710.0|
|100mg||In-stock||USD 1300.0 1300.0|
|Cat. No. :||CS-0064464|
|CAS No. :||2115701-93-2|
|M. Wt. :||437.95|
|Solubility:||10 mM in DMSO|
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. IC50 & Target: 10.4 nM (BET). In Vitro: (+)-JQ1 PA is a derivative of JQ1, which is the inhibitor of BET. The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells.
Protocol:Cell Assay: Proliferation of MV4;11 cells after 72 hours of treatment, comparing JQ1 versus JQ1-PA are tested. Cell cycle profile of MV4;11 cells after 48 hours of treatment with DMSO, JQ1, JQ1-PA, or JQ1-TCO (all compounds used at 500 nM) are tested.
Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.
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