Ferulic acid sodium
CAS No. : 24276-84-4

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  • Data Sheet

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Name: Ferulic acid sodium; Sodium ferulate
Cat. No. : CS-5275
CAS No. : 24276-84-4
Formula: C10H9NaO4
M. Wt. : 216.17
Solubility: DMSO: 16.66 mg/mL

Activity:

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in several plants with claimed beneficial effects in prevention and treatment of disorders linked to oxidative stress and inflammation. IC50 value: Target: 5-HT Receptor In vitro: In the present study we have showed that pre-treatment with Ferulic Acid (FA) reduces NO accumulation in the culture medium of LPS-induced macrophage cells. Moreover, real-time experiments have revealed that FA has an inhibitory effect at the transcriptional level on the expression of some inflammatory mediators such as IL-6, TNF-α and iNOS and an activation effect on the expression of some antioxidant molecules such as Metallothioneins (MT-1, MT-2). Importantly, we have found that FA reduced the translocation of NF-E2-related factor 2 (Nrf2) and nuclear transcription factor-κB (NF-κB) into the nuclei through a reduction of the expression of phosphorylated IKK and consequently inhibited IL-6 and NF-κB promoter activity in a luciferase assay [1]. FA treatment significantly, although not completely, protected the cells against lead acetate-induced neurite outgrowth inhibition. The effects of FA could be blocked by PD98059, zinc protoporphyrin (Zn-PP), and Nrf2 shRNA. In addition, FA induced heme oxygenase 1 (HO-1) gene expression, enhanced antioxidant response element (ARE) promoter activity, promoted ERK1/2 phosphorylation, and Nrf2 translocation in PC12 cells exposed to lead acetate. ERK1/2 locate upstream of Nrf2 and regulate Nrf2-dependent HO-1 expression in antioxidative effects of FA [2]. In vivo: We aimed to verify the possible antidepressant-like effect of acute oral administration of Ferulic acid produced an antidepressant-like effect in the FST and TST (0.01–10 mg/kg, p.o.), without ccompanying changes in ambulation. The pretreatment of mice with WAY100635 (0.1 mg/kg, s.c., a selective 5-HT1A receptor ntagonist) or ketanserin (5 mg/kg, i.p., a 5-HT2A receptor ntagonist) was able to reverse the anti-immobility effect of ferulic acid (0.01 mg/kg, p.o.) in the TST. The combination of fluoxetine (5 mg/kg, p.o.), paroxetine (0.1 mg/kg, p.o.) or sertraline (1 mg/kg, p.o.) with a sub-effective dose of ferulic acid (0.001 mg/kg, p.o.) produced a synergistic antidepressant-like effect in the TST, without causing hyperlocomotion in the open-field test. ferulic acid in the forced swimming test (FST) and tail suspension test (TST) in mice [3].

Protocol:

Animal administration [3] In order to investigate the antidepressant-like effect of ferulic acid, it was administered at a dose range of 0.001–10 mg/kg, by oral route (p.o.) 60 min before the FST, TST or open-field test. To address some of the mechanisms by which ferulic acid exerts antidepressant-like action in the TST, animals were pre-treated with different pharmacological agents. To investigate a possible contribution of the serotonergic system (5-HT receptor subtypes) in the antidepressant-like effect of ferulic acid, animals were pretreated with WAY100635 (0.1 mg/kg, a selective 5-HT1A receptor antagonist) by subcutaneous route (s.c.), ketanserin (5 mg/kg, a preferential 5-HT2A receptor antagonist) by intraperitoneal route (i.p.), or vehicle and after 30 min, received ferulic acid (0.01 mg/kg, p.o.) or vehicle before being tested in the TST 60 min later. The drugs were administered in a volume of 10 mL/kg body weight.

References:

Lampiasi N, et al. The molecular events behind ferulic acid mediated modulation of IL-6 expression in LPS-activated Raw 264.7 cells. Immunobiology. 2015 Nov 10.

Yu CL, et al. Ferulic Acid Protects Against Lead Acetate-Induced Inhibition of Neurite Outgrowth by Upregulating HO-1 in PC12 Cells: Involvement of ERK1/2-Nrf2 Pathway. Mol Neurobiol. 2015 Nov 26.

Ana Lúcia B. Zeni, et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: Evidence for the involvement of the serotonergic system. European Journal of Pharmacology 679 (2012) 68–74

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