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CAS No. : 287194-40-5
|Size||Stock||Price||Quantity||Add to Cart||Quotation Online|
|Cat. No. :||CS-5488|
|CAS No. :||287194-40-5|
|M. Wt. :||261.23|
|Solubility:||DMSO: ≥ 32 mg/mL|
(–)-DHMEQ is a potent NF-κB inhibitor. IC50 & Target: NF-κB In Vitro: (–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations.
Protocol:Cell Assay: A549 cells transfectants stably expressing RelB WT and RelB (C144S) are preincubated with various concentrations of (-)-DHMEQ (1, 5, 10, 25, and 50 μM) for 1h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (-)-DHMEQ.Cytoplasmic and nuclear extracts are analyzed by Western blotting.
Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677.
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