CAS No. : 287194-40-5

Size Stock Price Quantity Add to Cart Quotation Online
2mg In-stock USD 168.0
5mg In-stock USD 264.0
10mg In-stock USD 360.0
25mg In-stock USD 720.0
Products are for research use only. Not for human use. We do not sell to patients.

Bulk Inquiry

Your information is safe with us. * Required Fields
* Country or Region:
* Applicant name:
* Organization Name:
* Email address:
* Requested quantity:
* Phone number:
Organization name, 
Email address, 
Requested quantity, 
Phone number, 
  • Data Sheet

  • Introduction

  • SDS

  • COA & Spectra

Name: (-)-DHMEQ; Dehydroxymethylepoxyquinomicin
Cat. No. : CS-5488
CAS No. : 287194-40-5
Formula: C13H11NO5
M. Wt. : 261.23
Solubility: DMSO: ≥ 32 mg/mL


(–)-DHMEQ is a potent NF-κB inhibitor. IC50 & Target: NF-κB[1] In Vitro: (–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1].


Cell Assay: [1]A549 cells transfectants stably expressing RelB WT and RelB (C144S) are preincubated with various concentrations of (-)-DHMEQ (1, 5, 10, 25, and 50 μM) for 1h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (-)-DHMEQ.Cytoplasmic and nuclear extracts are analyzed by Western blotting[1].


Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677.

Enter Lot Number:

We apologize for the inconvenience. The Certificate of Analysis you requested is not currently available on-line:

1. The Lot Number you requested may have been entered incorrectly. How to get a Lot Number

2. The COA of the Lot you requested has not been added to our database.

Browsing History
    Other Forms
    Tags:(-)-DHMEQ supplier,(-)-DHMEQ purchase,(-)-DHMEQ manufacturer,(-)-DHMEQ sigma,(-)-DHMEQ distributor,cost,(-)-DHMEQ buy,(-)-DHMEQ for sale
    Please enter your email address
    Organization name: Email:

    Submit success

    No information on this batch number
    How to get a Lot Number

    Lot numbers can be found on the outside label of a product:

    ChemScene Label