Ornipressin is a potent vasoconstrictor agent, and plasma volume expansion with albumin to improve effective arterial blood volume.
In vitro: Ornipressin produces a profound vasoconstrictive effect by contracting smooth-muscle cells in the vascular bed, especially in capillaries, small arterioles and venules. Ornipressin is most commonly used to treat bleeding oesophageal varices.
Protocol:
References:
Henn EW et al. Effect of vaginal infiltration with ornipressin or saline on intraoperative blood loss during vaginal prolapse surgery: a randomised controlled trial. Int Urogynecol J. 2016 Mar;27(3):407-12.
Guevara M et al. Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology. 1998 Jan;27(1):35-41.
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