Enzyme Cleavable Linkers (Cleave Motif)
There are specific enzymes in the intracellular lysosomes and tumor microenvironment that can selectively cleave linkers. For example, cathepsins in lysosomes can hydrolyze peptide bonds, such as dipeptide or tetrapeptide linkers. Glycosidases that hydrolyze β-glucuronide and β-galactosidase, phosphatases that hydrolyze pyrophosphate and pyrophosphate, and sulfatases that hydrolyze sulfates.
Technical Resources
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Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiralChiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands
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2Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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3Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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4Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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5Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
Related Classifications
- Biotins, Streptavidins
- Functionality Creating Reagents
- Functional Group Blocking Reagents
- Heterobifunctional Cross-Linkers
- PEGylation Reagents and PEG Spacers
- Zero-length Crosslinkers
- Albumin Binding Modification Reagents
- Homobifunctional Cross-Linkers
- Copper-free Click Reaction Reagents
- Photo-reactive Crosslinkers
- N-Terminal Cysteine Residue-specific Conjugation Reagents