Classified by application
Signaling Pathways
-
Anti-infection
- Anti-infection
- Antibiotic
- Arenavirus
- Bacterial
- Beta-lactamase
- CMV
- Dengue Virus
- EBV
- Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
- Enterovirus
- Filovirus
- Flavivirus
- Fungal
- HBV
- HCV
- HCV Protease
- Hepatitis A Virus (HAV)
- Hepatitis E Virus (HEV)
- HIV
- HIV Protease
- HPV
- HSV
- Influenza Virus
- Orthopoxvirus
- Parasite
- Penicillin-binding protein (PBP)
- RABV
- Reverse Transcriptase
- RSV
- SARS-CoV
- TMV
- Tomato Spotted Wilt Virus (TSWV)
- Urease
- Virus Protease
- VSV
- Antibody-drug Conjugate/ADC Related
- Apoptosis
- Autophagy
-
Cell Cycle/DNA Damage
- Cell Cycle/DNA Damage
- Antifolate
- APC
- ATF6
- ATM/ATR
- Aurora Kinase
- CAPRIN1
- Casein Kinase
- CDK
- CDKL
- Checkpoint Kinase (Chk)
- ClpP
- CRISPR/Cas9
- Cyclin G-associated Kinase (GAK)
- Deubiquitinase
- DNA Alkylator/Crosslinker
- DNA Stain
- DNA-PK
- DNA/RNA Synthesis
- Early 2 Factor (E2F)
- Endonuclease
- Eukaryotic Initiation Factor (eIF)
- FKBP
- Folate Receptor (FR)
- G-quadruplex
- Haspin Kinase
- HDAC
- Hec1
- HMG Family
- HSP
- Ink4 Family
- IRE1
- Kinesin
- LIM Kinase (LIMK)
- MARK
- MASTL
- Microphthalmia Associated Transcription Factor (MITF)
- Microtubule/Tubulin
- Microtubule‐associated serine/threonine kinase (MAST)
- Mps1
- NEKs
- Nucleoside Antimetabolite/Analog
- p97
- PAK
- PARP
- PDI
- PERK
- Polo-like Kinase (PLK)
- Poly(ADP-ribose) Glycohydrolase (PARG)
- PPAR
- RAD51
- ROCK
- Separase
- Sirtuin
- SRPK
- STK33
- SWI/SNF Complex
- Telomerase
- TOPK
- Topoisomerase
- Wee1
- YB-1
- Zinc Finger Protein
- Cytoskeleton
-
Epigenetics
- Epigenetics
- AMPK
- Aurora Kinase
- DNA Glycosylase
- DNA Methyltransferase
- Epigenetic Reader Domain
- Glycosyltransferase
- HDAC
- Histone Acetyltransferase
- Histone Demethylase
- Histone Methyltransferase
- hnRNP
- HuR
- JAK
- Methionine Adenosyltransferase (MAT)
- METTL3
- MicroRNA
- PARP
- PKC
- Protein Arginine Deiminase
- RNA MTase
- S-adenosylhomocysteine hydrolase (SAHH)
- SAGA Complex
- SF3B1
- Sirtuin
- Small Interfering RNA (siRNA)
- TET Protein
- WDR5
- YTHDF
-
GPCR/G Protein
- GPCR/G Protein
- 5-HT Receptor
- Adenosine Receptor
- Adenylate Cyclase
- Adhesion G Protein-coupled Receptors (AGPCRs)
- Adrenergic Receptor
- Amylin Receptor
- Angiotensin Receptor
- Apelin Receptor (APJ)
- Arf Family GTPase
- Arrestin
- Bombesin Receptor
- Bradykinin Receptor
- Cannabinoid Receptor
- CaSR
- CCR
- CGRP Receptor
- Chemerin (RARRES2)
- Chemerin Receptor
- Cholecystokinin Receptor
- CRFR
- CRTH2 (GPR44)
- CXCR
- Dopamine Receptor
- EBI2/GPR183
- Endothelin Receptor
- Formyl Peptide Receptor (FPR)
- Free Fatty Acid Receptor
- G protein-coupled Bile Acid Receptor 1
- G Protein-coupled Receptor Kinase (GRK)
- G2A (GPR132)
- GCGR
- GHSR
- GLP Receptor
- GnRH Receptor
- GPR109A
- GPR119
- GPR139
- GPR171
- GPR35
- GPR4
- GPR52
- GPR55
- GPR6
- GPR65
- GPR68
- GPR84
- GPR88
- Guanylate Cyclase
- Histamine Receptor
- Hydroxycarboxylic Acid Receptor (HCAR)
- ICMT
- Kisspeptin Receptor
- Leukotriene Receptor
- LPL Receptor
- mAChR
- Mas-related G-protein-coupled Receptor (MRGPR)
- MCHR1 (GPR24)
- Melanocortin Receptor
- Melatonin Receptor
- mGluR
- Motilin Receptor
- Natriuretic Peptide Receptor (NPR)
- Neurokinin Receptor
- Neuromedin U Receptor (NMUR)
- Neuropeptide B/W Receptor
- Neuropeptide FF Receptor
- Neuropeptide S Receptor
- Neuropeptide Y Receptor
- Neurotensin Receptor
- Olfactory Receptor
- Opioid Receptor
- Orexin Receptor (OX Receptor)
- Orphan GPCR
- Orphan Receptor
- Oxytocin Receptor
- P2Y Receptor
- PACAP Receptor
- Platelet-activating Factor Receptor (PAFR)
- Prokineticin Receptor (PKR)
- Prostaglandin Receptor
- Protease Activated Receptor (PAR)
- PTHR
- Ras
- RGS Protein
- RXFP Receptor
- Secretin Receptor
- Somatostatin Receptor
- Succinate Receptor 1
- Taste Receptor
- Trace Amine-associated Receptor (TAAR)
- TSH Receptor
- Urotensin Receptor
- Vasopressin Receptor
-
Immunology/Inflammation
- Immunology/Inflammation
- AIM2
- ALCAM/CD166
- AP-1
- Arginase
- Aryl Hydrocarbon Receptor
- Asialoglycoprotein Receptor (ASGPR)
- BCL6
- C-type Lectin-like Receptors (CTLRs)
- CCR
- CD1
- CD19
- CD2
- CD20
- CD22
- CD276/B7-H3
- CD28
- CD3
- CD38
- CD44
- CD47
- CD6
- CD73
- CD74
- Complement System
- COX
- CRTH2 (GPR44)
- CTLA-4
- CX3CR1
- CXCR
- Cyclic GMP-AMP Synthase
- Cyclophilin
- DOCK
- E-Selectin
- FAP
- Fc Receptor (FcR)
- FKBP
- FLAP
- Galectin
- Glucocorticoid Receptor
- Glycoprotein VI
- Histamine Receptor
- Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
- IFNAR
- IKZF Family
- Interleukin Related
- IRAK
- Kallikrein
- L-Selectin
- LAG-3
- LANCL
- Macrophage migration inhibitory factor (MIF)
- Mesothelin
- MHC
- Mucin
- MyD88
- Nectin-4
- NO Synthase
- NOD-like Receptor (NLR)
- NTPDase
- Nuclear Factor of activated T Cells (NFAT)
- Osteopontin
- P-selectin
- PD-1/PD-L1
- PGE synthase
- Programmed Cell Death 4 (PDCD4)
- PSMA
- Pyroptosis
- Reactive Oxygen Species (ROS)
- S100 Protein
- Salt-inducible Kinase (SIK)
- Scavenger Receptor Class B type I (SR-BI）
- SOD
- SphK
- STING
- Thrombopoietin Receptor
- Tim3
- Toll-like Receptor (TLR)
- Transmembrane Glycoprotein
- TREM receptor
- TROP2
- VAP-1
-
JAK/STAT Signaling
- JAK/STAT Signaling
- EGFR
- Erythropoietin Receptor (EpoR)
- JAK
- Pim
- STAT
- MAPK/ERK Pathway
-
Membrane Transporter/Ion Channel
- Membrane Transporter/Ion Channel
- Amino acid Transporter
- Anion Exchangers
- Apical Sodium-Dependent Bile Acid Transporter
- Aquaporin
- ASCT
- ATP Synthase
- ATP-binding cassette (ABC) transporters
- BCRP
- Calcium Channel
- Calmodulin
- CFTR
- Chloride Channel
- CRAC Channel
- CRM1
- EAAT
- EHD Protein
- FATP
- Ferlin Family
- Ferroportin
- GABA Receptor
- GLUT
- Glycine Receptor (GlyR)
- GlyT
- HCN Channel
- iGluR
- Monoamine Transporter
- Monocarboxylate Transporter
- Na+/Ca2+ Exchanger
- Na+/H+ Exchanger (NHE)
- Na+/HCO3- Cotransporter
- Na+/K+ ATPase
- nAChR
- NKCC
- Nucleoside Transporters
- OAT
- Oligopeptide Cotransporter
- P-glycoprotein
- P2X Receptor
- Piezo Channel
- Potassium Channel
- Proton Pump
- Sec Translocon
- Sec61
- SGLT
- SLC39 (Zinc Transporter)
- Sodium Channel
- Sodium Chloride Cotransporter (NCC)
- Sodium Phosphate Cotransporter
- Synaptic Vesicle Proteins
- TRP Channel
- URAT1
- Urea Transporter
- VDAC
- WNK Kinase
-
Metabolic Enzyme/Protease
- Metabolic Enzyme/Protease
- 11β-HSD
- 15-PGDH
- 17β-HSD
- 3β-HSD
- 5 alpha Reductase
- Acetolactate Synthase (ALS)
- Acetyl-CoA Carboxylase
- Acetyl-CoA Carboxylase
- Acetyl-CoA synthetase
- Acyltransferase
- ADAMTS
- Adenosine Deaminase
- Adenosine Kinase
- Adiponectin Receptor
- Aldehyde Dehydrogenase (ALDH)
- Aldehyde Oxidase (AO)
- Aldose Reductase
- Amine N-methyltransferase
- Amino Acid Oxidase
- Aminoacyl-tRNA Synthetase
- Aminopeptidase
- Aminotransferases (Transaminases)
- Amylases
- Angiotensin-converting Enzyme (ACE)
- ANGPTL
- Apolipoprotein
- Arginase
- ATGL
- ATP Citrate Lyase
- Branched Chain Amino Acid Transaminase (BCAT)
- Carbamoyl Phosphate Synthetase (CPS)
- Carbonic Anhydrase
- Carbonyl Reductase
- Carboxylesterase (CES)
- Carboxypeptidase
- Carnosine-cleaving Enzyme
- Cathepsin
- Ceramidase
- Ceramide Transport Protein (CERT)
- CETP
- COMT
- Creatine Kinase
- Cryptochrome
- Cytochrome P450
- DAGL
- DGK
- Dihydroceramide Desaturase 1 (DES1)
- Dihydrofolate reductase (DHFR)
- Dihydroorotate Dehydrogenase
- Dihydropyrimidine Dehydrogenase (DPD)
- Dipeptidyl Peptidase
- Dopamine β-hydroxylase
- Drug Metabolite
- E1/E2/E3 Enzyme
- Elastase
- ELOVL
- Emopamil Binding Protein
- Endogenous Metabolite
- Endothelin-Converting Enzyme (ECE)
- Enolase
- Enteropeptidase
- Epoxide Hydrolase
- FAAH
- FABP
- Factor VIIa
- Factor VIII
- Factor Xa
- Factor XI
- Farnesyl Transferase
- Fat Mass and Obesity-associated Protein (FTO)
- Fatty Acid Synthase (FASN)
- FBPase
- Ferrochelatase
- FMN-dependent α-hydroxyacid oxidase enzyme
- FOXO
- Furin
- FXR
- Galactokinase
- GGPPS
- GGTase
- GHR
- Glucokinase
- Glucose-6-Phosphate Isomerase (GPI)
- Glutamate Dehydrogenase (GLDH)
- Glutamate Dehydrogenase (GLDH)
- Glutaminase
- Glutathione Peroxidase
- Glutathione Reductase (GR)
- Glutathione S-transferase
- Glycogen Synthase
- Glycosidase
- Glyoxalase (GLO)
- GSNOR
- HCV Protease
- Heme Oxygenase (HO)
- Hemoglobin
- Herbicide
- Hexokinase
- Hexosaminidase
- HIF/HIF Prolyl-Hydroxylase
- HIT protein superfamily
- HIV Integrase
- HIV Protease
- HMG-CoA Reductase (HMGCR)
- Hormone-Sensitive Lipase (HSL)
- HPPD
- HRASLS
- HSP
- Hydroxy Acid Oxidase A
- Hydroxyindole-O-methyltransferase (HIOMT)
- IDE
- IMPDH
- Indoleamine 2,3-Dioxygenase (IDO)
- IPK Superfamily
- Isocitrate Dehydrogenase (IDH)
- Ketohexokinase
- KMO
- Lactate Dehydrogenase
- LDLR
- Lipase
- Liposome
- Lipoxygenase
- Liver kinase B1 (LKB1)
- LOX-1
- LXR
- MAGL
- Malate Dehydrogenase (MDH)
- Malonyl-CoA Decarboxylase
- MALT1
- Membrane-associated Guanylate Kinase (MAGUK)
- MetAP
- Methionine Adenosyltransferase (MAT)
- Methylenetetrahydrofolate Dehydrogenase (MTHFD)
- Microsomal Triglyceride Transfer Protein (MTP)
- Mineralocorticoid Receptor
- Mitochondrial Metabolism
- Mitogen- and Stress-Activated Protein Kinase (MSK)
- MMP
- Myotonin-Protein Kinase (DMPK)
- N-myristoyltransferase
- NADH Dehydrogenase
- NADPH Oxidase
- NAMPT
- NDR Family
- NEDD8-activating Enzyme
- Nemo-like kinase (NLK)
- Neprilysin
- Neuropathy Target Esterase (NTE)
- Ornithine decarboxylase (ODC)
- Oxidative Phosphorylation
- Oxysterol-binding Protein-related Protein (ORP)
- PAI-1
- Palmitoyl Protein Thioesterase (PPT)
- PANK
- PCSK9
- PDHK
- PDI
- PEPCK
- PGC-1α
- Phenylalanine Ammonia-Lyase
- Phosphatase
- Phosphatidylcholine Transfer Protein (PC-TP)
- Phosphodiesterase (PDE)
- Phosphoglycerate Dehydrogenase (PHGDH)
- Phosphoglycerate Kinase (PGK)
- Phospholipase
- Phosphomannose Isomerase (PMI)
- Phosphorylase
- Photosystem II
- PI4P5K
- PI5P4K
- PPAR
- Procollagen C Proteinase
- Prolyl Endopeptidase (PREP)
- Proteasome
- Protein Prenyltransferase
- Proteolytic Enzyme
- Protoporphyrinogen IX oxidase
- Pyruvate Carboxylase (PC)
- Pyruvate Kinase
- Pyruvate Oxidase
- Quinone Reductase
- RAR/RXR
- Reactive Oxygen Species (ROS)
- Renin
- REV-ERB
- ROR
- RPE65
- S-adenosylhomocysteine hydrolase (SAHH)
- Sepiapterin Reductase
- Ser/Thr Kinase
- Ser/Thr Protease
- Serine Racemase (SR)
- Sex Pheromone
- SGK
- SHMT
- Sialyltransferase
- SPFH Protein Superfamily
- Squalene Monooxygenase
- Squalene Synthase
- Stearoyl-CoA Desaturase (SCD)
- Steroid Sulfatase
- Succinate Dehydrogenase
- SULT
- Thrombin
- Transglutaminase
- Transketolase
- TrxR
- Tryptophan Hydroxylase
- Tyrosinase
- Tyrosine Hydroxylase
- UGT
- Xanthine Oxidase
- β-glucuronidase
- γ-Glutamyl Transferase (GGT)
-
Neuronal Signaling
- Neuronal Signaling
- 5-HT Receptor
- AAK1
- Adenosine Kinase
- Adrenergic Receptor
- Amyloid-β
- Aromatic L-amino acid decarboxylase (AADC)
- Beta-secretase
- Calcineurin
- Calcium Channel
- CaMK
- Cannabinoid Receptor
- CGRP Receptor
- Cholecystokinin Receptor
- Choline Kinase
- Cholinesterase (ChE)
- COMT
- Dihydroceramide Desaturase 1 (DES1)
- Dimethylargininase (DDAH)
- Dopamine Receptor
- Dopamine Transporter
- FAAH
- GABA Receptor
- Glucosylceramide Synthase (GCS)
- GlyT
- GPR119
- GPR139
- GPR55
- Histamine Receptor
- Huntingtin
- iGluR
- Imidazoline Receptor
- Legumain
- mAChR
- MCHR1 (GPR24)
- Melanocortin Receptor
- Melatonin Receptor
- mGluR
- Monoamine Oxidase
- nAChR
- Neurokinin Receptor
- Neuropeptide Y Receptor
- Neurotensin Receptor
- Nogo Receptor (NgR)
- Notch
- OGA
- OGT
- Olfactory Receptor
- OLIG2
- Opioid Receptor
- Orexin Receptor (OX Receptor)
- PINK1/Parkin
- Prion Protein
- Prion Protein
- PrP
- Serotonin Transporter
- Sigma Receptor
- Slit Proteins
- Somatostatin Receptor
- Tau Protein
- Transthyretin (TTR)
- Trk Receptor
- TRP Channel
- TSPO
- α-synuclein
- γ-secretase
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
-
Protein Tyrosine Kinase/RTK
- Protein Tyrosine Kinase/RTK
- Ack1
- Anaplastic lymphoma kinase (ALK)
- Bcr-Abl
- BMX Kinase
- BRK
- Btk
- c-Fms
- c-Kit
- c-Met/HGFR
- Discoidin Domain Receptor
- DYRK
- EGFR
- Ephrin Receptor
- FAK
- FGFR
- FLT3
- GDNF Receptor
- IGF-1R
- Insulin Receptor
- Itk
- JAK
- PDGFR
- Pyk2
- RET
- ROS Kinase
- SHP1
- SHP2
- Src
- Syk
- TAM Receptor
- Tie
- TNK1
- Trk Receptor
- VEGFR
- Stem Cell/Wnt
-
TGF-beta/Smad
- TGF-beta/Smad
- Dan family
- PKA
- PKC
- ROCK
- RUNX
- TGF-beta/Smad
- TGF-β Receptor
-
Vitamin D Related/Nuclear Receptor
- Vitamin D Related/Nuclear Receptor
- Androgen Receptor
- Constitutive Androstane Receptor
- Estrogen Receptor/ERR
- Glucocorticoid Receptor
- LXR
- Mineralocorticoid Receptor
- Nuclear Hormone Receptor 4A/NR4A
- Nuclear Hormone Receptor 4A/NR4A
- Orphan Nuclear Receptor
- PPAR
- Pregnane X Receptor (PXR)
- Pregnane X Receptor (PXR)
- Progesterone Receptor
- RAR/RXR
- REV-ERB
- ROR
- Thyroid Hormone Receptor
- VD/VDR
- VKOR
- Others