Non-cleavable linker
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Non-cleavable linkers fall into two categories, thioether or maleimidocaproyl (MC), which consist of a stable bond that prevents proteolytic cleavage. ADCs with this type of linker rely on lysosomal enzyme degradation to release the payload after internalization, resulting in simultaneous detachment of the linker.
Non-cleavable linker
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Monofunctional group
Bifunctional group
Trifunctional group
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