Organocatalytic Small Molecules

Amino Acids

Amino acid ligands have been widely used in organic synthesis, asymmetric catalysis and metal catalysis due to their excellent chiral induction ability, multifunctionality and good coordination with metals. With the deepening of the understanding of the structure and catalytic mechanism of amino acid ligands, more efficient and selective catalytic systems are expected to be developed in the future to promote their application in chemical synthesis and green chemistry.

Chiral Phase Transfer Catalysts

Chiral phase transfer catalysts are a type of catalyst that can promote phase transfer reactions and have chiral centers that can control stereoselectivity in the reaction, thereby achieving asymmetric synthesis. Phase transfer catalysis is a process that can transfer reactants from an immiscible solvent to another phase (for example, from an aqueous phase to an organic phase) for reaction. Chiral phase transfer catalysts add chiral elements to this basis and control the enantioselectivity of the product in the reaction through their chiral centers.

Chiral Phosphonic Acid

As an important chiral catalyst, chiral phosphonic acid has outstanding performance in asymmetric catalysis, CH activation, acid-catalyzed reaction and other fields due to its unique acidic center and chiral environment. It can regulate the electronic structure and spatial configuration of reactants through protonation, hydrogen bonding and other means, thereby providing highly selective products. Although chiral phosphonic acid has many advantages in catalytic reactions, its synthesis and reaction conditions are still challenges in application.

Chiral Phosphoramidite

Chiral phosphinamides are a class of highly active and selective ligands that can play an important role in metal-catalyzed asymmetric reactions. They have a wide range of applications in organic synthesis by providing a stable metal coordination environment, regulating the stereoselectivity of reactions, and improving the efficiency of catalytic reactions. The design and synthesis of efficient chiral phosphinamide ligands are of great significance for improving the selectivity and reaction rate of catalytic reactions, and remain an active research area in future catalytic research.

Chiral Squaramide

Chiral squaramides are widely used as catalysts in asymmetric synthesis. They can promote various chemical reactions and control the stereochemistry of products through their unique hydrogen bonding, stereoselectivity and electronic effects. Chiral squaramides have important application prospects in the fields of drug synthesis and materials science. With the continuous advancement of catalyst design, chiral squaramides are expected to play a greater role in more complex organic synthesis reactions.

Chiral Trifluorophosphamide

As an important chiral catalyst, chiral trifluorophosphamide has strong acidity, hydrogen bond acceptance and chiral regulation ability. It has a wide range of applications in asymmetric catalysis, acid-catalyzed reactions, metal-catalyzed reactions and other fields, and can improve the selectivity and efficiency of reactions. Although there are certain challenges in synthesis, its unique advantages in organic synthesis and catalytic reactions make it an important tool in catalytic chemistry.

Chiral Urea/Thiourea

Chiral urea/thiourea compounds play an important role in asymmetric catalytic reactions as catalyst ligands or catalysts themselves. They can significantly improve the selectivity and efficiency of catalytic reactions through hydrogen bond donor effects, metal coordination, and stereo control. Whether in metal-catalyzed reactions or reactions that do not rely on metal catalysis, chiral urea/thiourea can provide strong support for efficient organic synthesis.

Cinchona

Sodium cinchona catalysts can effectively promote some specific chemical reactions by changing the electronic properties of the reaction system and stabilizing the intermediate species of the reaction, especially showing good catalytic performance in metal catalysis, asymmetric catalysis and other reactions. Although there are some challenges, sodium cinchona catalysts still show a relatively broad application prospect in the fields of organic synthesis and green chemistry.

Other Catalytic Small Molecules