Azide

The reaction of azide with alkyne is one of the classic reactions in click chemistry, known as the copper-catalyzed [3+2] cycloaddition reaction. The five-membered ring compound generated by this reaction has good selectivity and high yield, and is an effective method for building complex molecules. Azide can not only react with alkyne, but also undergo click chemistry reactions with other reactants (such as cyclooctyne, isocyanate, etc.), expanding the diversity of chemical synthesis. Azide can be combined with biological macromolecules (such as proteins, nucleic acids, etc.) to achieve specific labeling and tracking.