Cholesterol
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Cholesterol plays a role in regulating membrane fluidity, stability and encapsulation efficiency in LNPs. Cholesterol enhances the stability of nanoparticles by filling the gaps between lipids, helps to fuse with the endosomal membrane during cell absorption, and facilitates cell uptake, thereby improving the delivery efficiency of nucleic acids.
Cholesterol
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Monofunctional group
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Trifunctional group
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