Click Chemistry Reagents

Click Chemistry is a type of reaction proposed by K. Barry Sharpless, a Nobel Prize winner in Chemistry and a researcher at the Institute of Chemical Biology at the Skaggs Institute. This type of reaction is generally high-yielding, has a wide range of applications, produces a single byproduct that does not need to be separated by a chromatographic column, has stereoselectivity, is easy to operate, and the reaction solvent is easy to remove. This concept is also applicable to other fields, such as medicine and materials, and can synthesize a large number of compound libraries for research in other fields. There are many types of reactions that produce only one product by thermodynamics that meet the conditions of click chemistry, such as the nucleophilic ring-opening reaction of ethylene oxide and azocyclopropane, the reaction of non-aldehyde carbonyl compounds (preparation of hydrazones or heterocyclic compounds), and the reaction of CC double bonds and triple bonds (such as oxidation to prepare epoxides, and Michael addition and cycloaddition reactions, etc.).