Cleavable Linkers

Cleavable linkers contain chemical triggers that can be cleaved to release the payload, and are highly flexible. The released payload can diffuse into surrounding cells, exerting a bystander effect. Cleavable linkers are divided into chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers include acid-cleavable linkers (hydrazone bonds) and reducible linkers (disulfide bonds). Enzymatically cleavable linkers include peptide linkers and glucosidase-type linkers.