Halogen-modified Nucleosides

Halogen-modified nucleotides refer to a type of chemical modification that introduces halogen atoms (such as fluorine, chlorine, bromine or iodine) into the bases of natural nucleotides. This modification can significantly affect the chemical properties, biological activity and application of nucleotides in nucleic acid drugs. Halogen modification can enhance the stability, specificity, affinity and pharmacokinetic properties of nucleic acids and is often used in gene therapy, antiviral therapy and cancer therapy.