Chiral Phosphonic Acid

As an important chiral catalyst, chiral phosphonic acid has outstanding performance in asymmetric catalysis, CH activation, acid-catalyzed reaction and other fields due to its unique acidic center and chiral environment. It can regulate the electronic structure and spatial configuration of reactants through protonation, hydrogen bonding and other means, thereby providing highly selective products. Although chiral phosphonic acid has many advantages in catalytic reactions, its synthesis and reaction conditions are still challenges in application.