2-Methylpyridine-4-sulfonyl chloride

CAS No. 1025509-77-6
Cat. No. CS-0654588
Molecule weight191.64
Purity≥95%
MDL No.None

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2-Methylpyridine-4-sulfonyl chloride|CS-0654588

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General Information

CAS No. 1025509-77-6
Cat. No. CS-0654588
Purity ≥95%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClNO₂S
Molecular Weight 191.64
Synonym(s) None
SMILES CC1=NC=CC(=C1)S(=O)(=O)Cl

Description

2-Methylpyridine-4-sulfonyl chloride features a pyridine ring with methyl and sulfonyl chloride groups in a 2,4-arrangement, delivering a reactive electrophilic site for nucleophilic substitution. This configuration enhances solubility in organic solvents while maintaining stability under anhydrous conditions, enabling efficient incorporation into pharmaceutical intermediates and functionalized materials.

Application

2-Methylpyridine-4-sulfonyl chloride serves as a versatile sulfonylating agent in medicinal chemistry, enabling efficient introduction of the pyridylsulfonyl group into target molecules. Its reactivity facilitates amide and sulfonamide formation under mild conditions, with good bench stability and ease of purification. The methyl substituent enhances lipophilicity and can influence downstream metabolic properties, making it valuable for constructing bioactive scaffolds in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 47.03
LogP 1.31752
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Methylpyridine-4-sulfonyl chloride

CAS No. 1025509-77-6

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