Solid State Chemistry and Single Crystal Research
ChemScene has two major drug development platforms: a drug solid-state chemistry research technology platform and a single crystal platform. The drug solid-state chemistry research technology platform provides research services such as crystal/salt/eutectic screening, solid-state analysis, crystallization processes, etc; The single crystal platform provides research services such as single crystal cultivation, detection, and analysis, and also has crystal sponge technology to assist in single crystal detection, effectively solving the problem of structural identification of difficult to crystallize products. The two platforms focus on systematic research on the solid morphology and crystal form of drug molecules, providing systematic and professional technical services for the development of downstream formulations.
Crystal, salt, and eutectic screening
ChemScene conducts rapid, systematic, or targeted screening activities based on the needs of customers at different stages of drug molecule development. Normally, 100+experiments are conducted for crystal screening, with a period of approximately 6-8 weeks; 200+experiments were conducted for salt screening, with a period of approximately 10-12 weeks.
Special technology
A comprehensive screening system and technical means to accurately and efficiently obtain the optimal solid-state form required by customers Eutectic screening combined with surface electrostatic potential energy calculation, computer virtual screening, precise experiments.
- New drug discovery
- Preclinical studies
- Clinical phase I
- Clinical phase II
- Clinical phase III
- Commercial
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Screening of crystal and salt
forms for preliminary
determination of drug solid
form in pharmacological and toxicological studies -
Crystal and salt form screening for further selection of solid form for formulation development
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Comprehensive crystal
and salt screening for
NDA application -
Crystal and salt screening to
improve drug lifecycle
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6-8 weeks
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8-12 weeks
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3-6 months
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custom
Solid state analysis
| Analysis content | Equipment model | Sample size | Detection cycle | Data compliance |
|---|---|---|---|---|
| Differential scanning calorimetry analysis (DSC/mDSC) | TA Discovery DSC250 | 10mg | 3d | 3Q+Audit tracking |
| Thermogravimetric analysis (TGA) | TA Discovery TGA55 | 20mg | 3d | 3Q+Audit tracking |
| X-ray powder diffraction (XRPD) | D8 ADVANCE | 10mg | 3d | 3Q+Audit tracking |
| Particle size analysis (PSD) | Mastersizer 3000 | 500mg dry process 200mg wet process |
1-3d 1-3d |
3Q+Audit tracking 3Q+Audit tracking |
| Polarized light microscope (PLM) | XPL-2 | 5mg | 1-3d | Effective data management |
Single crystal cultivation, detection, and analysis
ChemScene focuses on providing one-stop efficient technical testing services for single crystal cultivation, structural testing, and structural analysis of drug molecules and their intermediate fragments. It is applied in drug molecule structure confirmation, trace impurity structure identification, and drug crystal form research and development.
- High throughput single crystal cultivation, quickly obtaining sample single crystals
- Accurate detection using Bruker D8 VENTURE dual micro focal spot single crystal X-ray diffractometer
- High level structural analysis
- Can perform structural analysis and correction on defective sample single crystals
Service Introduction
Single crystal culture
Experienced single-crystal cultivation technicians
Multiple high-throughput cultivation methods
The sample single crystal can be obtained in as fast as 12 hours
Single crystal test
The company is equipped with an advanced Bruker D8
VENTURE dual micro focal spot single crystal X-ray diffractometer
High timeliness, obtaining single crystal samples for immediate machine testing, completed in a few hours
Quickly adjust the single crystal cultivation method for unsatisfactory single crystal data and complete a new round of crystal cultivation within a few hours
Single crystal structure analysis
Experienced structural analysis technicians
High level analysts can perform structural analysis and correction on defective single crystal samples
The fastest time to complete testing and parsing is only one day
Structural confirmation
Chiral confirmation
Crystal confirmation
Accurate identification of trace unknown impurities or molecules
After purification and separation of unknown impurities as low as a few milligrams, precise structural and chiral information can be obtained through single crystal cultivation, testing, and structural analysis, solving the pain points of low efficiency and poor accuracy in conventional testing methods
Crystal sponge technology
Molecular visualization technology without the need for single crystal cultivation The required amount of sample theoretically can be at least in the nanogram (10-9g) range.
Difficult to crystallize solid powder
Trace drug impurities
Oil like molecules
Core technology
Leading crystal sponge platform technology, effectively solve the problem of difficult to identify solid powders and oily molecules that are difficult to crystallize, as well as impurities below the drug structure. The difficulty in identifying the impurity structure of drugs with a dosage of 1mg.
The core team has long been engaged in the research of single crystals (crystal sponges), with a solid theoretical foundation and rich practical experience in the preparation of crystal sponges, the study of the interaction mechanism between molecules and crystal sponges, as well as the cultivation, testing, and data analysis of single crystals.
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ADVANCED
Equipped with advanced Bruker D8 VENTURE single crystal diffractometer to ensure efficient satisfaction of customer needs
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FAST
Complete single crystal cultivation, testing, and analysis of samples within 2 days at the fastest, Addressing the pain points of low efficiency caused by the separation of the three stages of single crystal cultivation, testing, and analysis
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FULL
Both powder samples and oily samples (crystal sponge technoloav) can provide structural and chiral confirmation information
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ACCURATE
Accurate results can also be obtained by analyzing
defective single crystal samples -
HIGH THROUGHPUT
Cultivate single crystals using high-
throughput methods -
FULL
The minimum sample size can be
up to 10 mg
Crystallization Process Service
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Clearly define the target crystal structure
Design optimization plan
Optimize the preparation process
Determine key parameters
Improve crystal purity
Improve physical and chemical properties
Enhance medicinal properties
Realize process stability
Ensure process safety