Oligonucleotide Drug Process Service

ChemScene is equipped to meet customer needs for small to medium-scale trials. Our Oligo R&D team possesses extensive expertise in chemical modification, capable of over 100 functional modifications for diverse applications. These modifications offer a broad range of options for cellular experiments, animal studies, and clinical trials, addressing various customer needs in research, diagnostics, and therapeutic applications.

What We Can Offer

Capability
Nucleosides / Amidites from
mg to ton
Integrated Service
Complete production from monomer
to API
Expert Scientists
Teams with 10+ years of oligonucleotide
R&D experience

Oligonucleotide Integration Service Platform

Pre-Clincal
Phase I
Phase II
Phase III
Commercialization

Small Nucleic Acid Monomers Oligonucleic Acid APIs	Oligonucleic acid synthesis, process development and production
Analytical Chemistry	Analytical method development, quality control and stability studies
CMC Service	Full process CMC service support

The Types of Oligonucleotide Synthesis We Offer

RNA Synthesis
- • Small interfering RNA (siRNA)
- • CRISPR (sgRNA)
- • MicroRNA (miRNA)
- • Small activating RNA (saRNA)
Oligonucleotide Conjugation
- • GalNAc conjugated oligonucleotides
- • eptide conjugated oligonucleotides
- • Antibody conjugated oligonucleotides
DNA Synthesis
- • Antisense Oligonucleotides (ASO)
- • Gapmer
- • Aptamer
- • Vaccine adjuvant

Why Choose Us

Our Success Cases

Case 1 Product: ASO
- Number of bases : 18
- Modifications : Full chain methoxyethyl and thio modification
- Delivery quantity : 10 g
- Delivery time : 14 days
- Overall yield : 48%
Case 2 Product: siRNA
- Number of bases : ortho: 21; antisense: 23
- Modifications : Partial methoxylation, fluorination, thio-modification
- Delivery quantity : 1 g
- Delivery time : 14 days
- Overall yield : 42%

Our Nucleoside Monomer Display (from mg to ton)

Nucleosides

Commercial (ton)

CAS No.: 784-71-4 Purity: ≥99.9%

2'-Fluoro-2'- deoxyuridine
Pilot (kg)

CAS No.: 64183-27-3 Purity: ≥99.5%

2'-Fluoro-2'- deoxyadenosine
Pilot (kg)

CAS No.: 69504-07-0 Purity: ≥99%

N6-ben Zoyl-2’-O-[(1,1- dimethylethyl) dimethylsilyl]-Adenosine
Pilot (kg)

CAS No.: 182007-86-9 Purity: ≥98%

2’-O-[(1,1-dimethylethyl) dimethylsilyl]-N-(2-methyl- 1-oxopropyl)-Guanosine
Pilot (kg)

CAS No.: 54925-71-2 Purity: ≥98%

2’-O-[(1,1- dimethylethyl) dimethylsilyl]-Uridine
Pilot (kg)

CAS No.: 401812-97-3 Purity: ≥98.5%

N-acetyl-2’-O- [(1,1-dimethylethyl) dimethylsilyl]-Cytidine

Amidites

Pilot (kg)

CAS No.: 110764-79-9 Purity: 98%

DMT-2'-O-Me-U-CE Phosphoramidite
R&D (kg)

CAS No.: 159414-99-0 Purity: 98%

DMT-2'-F-dC(Ac)-CE Phosphoramidite
R&D (kg)

CAS No.: 146954-75-8 Purity: 98%

DMT-2'-F-dU-CE Phosphoramidite
Pilot (kg)

CAS No.: 150780-67-9 Purity: 98%

2'-OMe-G(ibu) Phosphoramidite
R&D (kg)

CAS No.: 110543-74-3 Purity: 98%

DMT-dA(PAc) Phosphoramidite
R&D (kg)

CAS No.: 98796-51-1 Purity: 98%

DMT-dT Phosphoramidite

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Oligonucleotide Drug Process Service

What We Can Offer

Capability

Integrated Service

Expert Scientists

Oligonucleotide Integration Service Platform

The Types of Oligonucleotide Synthesis We Offer

RNA Synthesis

Oligonucleotide Conjugation

DNA Synthesis