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CS-W001157 4
Total: USD 88.00

N-((1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide Granisetron impurity

  • CAS No. 107007-95-4

  • Cat. No. CS-0531848
  • Molecule weight298.39
  • Purity≥98%
  • MDL No.MFCD00872014

*For research and further manufacturing use only, not for direct human use.

N-((1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide Granisetron impurity|CS-0531848

Structure of 107007-95-4

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General Information

  • CAS No. 107007-95-4
  • Cat. No. CS-0531848
  • Purity ≥98%
  • MDL No. MFCD00872014
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₂N₄O
  • Molecular Weight 298.39
  • Synonym(s) N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide
  • SMILES CN([C@@H](CCC1)C2)[C@H]1C[C@@H]2NC(C3=NNC4=CC=CC=C34)=O

Description

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.

Synthesis

  • Route1
    • exo-3-Amino-9-methyl-9-azabicyclo[3.3.1]nonane|CS-0049373
      76272-41-8
    • In-stock
      Indazole-3-carboxylic acid|CS-W002518
      4498-67-3
    • ~98%
    • In-stock
      N-((1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide Granisetron impurity|CS-0531848
      107007-95-4

    References

    • Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestr, Linda; Lummis, Sarah C. R.; Lochner, Martin Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2324 - 2328
  • Route2
    • exo-3-Amino-9-methyl-9-azabicyclo[3.3.1]nonane|CS-0049373
      76272-41-8
    • null|null
      115660-68-9
    • ~9%
    • In-stock
      N-((1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide Granisetron impurity|CS-0531848
      107007-95-4

    References

    • Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.02
  • LogP   2.308
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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