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6-Fluoro-2,3-dihydrobenzofuran

  • CAS No. 1072153-65-1

  • Cat. No. CS-0156844
  • Molecule weight138.14
  • Purity≥97%
  • MDL No.MFCD22536385

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-2,3-dihydrobenzofuran|CS-0156844

Structure of 1072153-65-1

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General Information

  • CAS No. 1072153-65-1
  • Cat. No. CS-0156844
  • Purity ≥97%
  • MDL No. MFCD22536385
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO
  • Molecular Weight 138.14
  • Synonym(s) 6-fluoro-2,3-dihydro-1-benzofuran
  • SMILES C1=CC(=CC2=C1CCO2)F

Description

6-Fluoro-2,3-dihydrobenzofuran is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 6-position and a saturated furan ring. This structural motif integrates readily into bioactive molecules, offering enhanced metabolic stability and modulated lipophilicity. Its rigid, planar geometry facilitates precise molecular positioning in target binding sites.

Application

6-Fluoro-2,3-dihydrobenzofuran serves as a versatile scaffold in medicinal chemistry, offering enhanced metabolic stability and modulated lipophilicity compared to its parent benzofuran. The fluorine substituent at the 6-position provides favorable electronic effects and improves binding affinity in target-directed synthesis. Its saturated furan ring enables compatibility with standard coupling reactions and functional group transformations, facilitating downstream derivatization. Bench-stable and readily purified by flash chromatography, it functions effectively as a building block for bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.7606
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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