2,4-Difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

CAS No. 1083326-73-1
Cat. No. CS-M0092
Purity≥95%
MDL No.MFCD12923393

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2,4-Difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide|CS-M0092

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Description

2,4-Difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide features a boronate ester handle enabling robust Suzuki-Miyaura coupling. The electron-deficient aryl sulfonamide integrates efficiently into complex molecular architectures under mild conditions. This bench-stable reagent pairs well with diverse partners in late-stage functionalization workflows.

Application

2,4-Difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pyridyl-borane moiety enables efficient C–C bond formation under mild conditions, while the sulfonamide and difluoro substituents provide orthogonal functionalization handles. Bench-stable and compatible with diverse reaction conditions, it facilitates rapid access to complex heterocyclic scaffolds in medicinal chemistry and materials synthesis.

General Information

CAS No. 1083326-73-1
Cat. No. CS-M0092
Purity ≥95%
MDL No. MFCD12923393
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₁BF₂N₂O₅S
Molecular Weight 426.24
Synonym(s) 3-(2,4-Difluorophenylsulfonylamino)-2-methoxypyridine-5-boronic acid pinacol ester
SMILES O=S(C(C(F)=C1)=CC=C1F)(NC2=C(OC)N=CC(B(OC(C)3C)OC3(C)C)=C2)=O

Computational Chemistry Data

TPSA 86.75
LogP 2.4684
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 5

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Sulfonamide

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2,4-Difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide

CAS No. 1083326-73-1

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