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CS-W001157 4
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Tert-butyl 2-(chloromethyl)pyrrolidine-1-carboxylate

  • CAS No. 1142400-61-0

  • Cat. No. CS-0272848
  • Molecule weight219.71
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 2-(chloromethyl)pyrrolidine-1-carboxylate|CS-0272848

Structure of 1142400-61-0

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General Information

  • CAS No. 1142400-61-0
  • Cat. No. CS-0272848
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈ClNO₂
  • Molecular Weight 219.71
  • Synonym(s) 1-BOC-2-Chloromethyl-pyrrolidine
  • SMILES CC(C)(C)OC(=O)N1CCCC1CCl

Description

Tert-butyl 2-(chloromethyl)pyrrolidine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a reactive chloromethyl group poised for nucleophilic substitution. The tert-butyl ester provides orthogonal protection, enabling selective deprotection under mild acidic conditions. This molecule integrates readily into complex molecular architectures via C–C or C–heteroatom bond formation.

Application

Tert-butyl 2-(chloromethyl)pyrrolidine-1-carboxylate serves as a versatile building block for constructing pyrrolidine-containing scaffolds in medicinal chemistry. The chloromethyl group enables efficient alkylation reactions, while the tert-butyl carbamate protects the amine under standard conditions. This reagent offers excellent bench stability, ease of purification, and compatibility with diverse functional groups, facilitating rapid access to complex heterocycles and API intermediates through well-established synthetic protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.6247
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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