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Structure of 1159983-77-3
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1-BOC-3-trifluoromethyl-piperidin-4-one features a sterically shielded trifluoromethyl group and a bench-stable Boc-protected carbonyl, enabling direct incorporation into complex heterocyclic scaffolds. The electron-withdrawing trifluoromethyl moiety enhances reactivity in nucleophilic substitution and facilitates downstream functionalization under mild conditions.
1-BOC-3-trifluoromethyl-piperidin-4-one serves as a versatile building block for the synthesis of trifluoromethylated piperidinone derivatives. The BOC group provides stability and ease of deprotection under mild acidic conditions, while the ketone functionality enables nucleophilic addition, reductive amination, and coupling reactions. Its trifluoromethyl substituent imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: