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CS-W001157 4
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5-Bromo-2-chloropyridin-4-ol

  • CAS No. 1196146-82-3

  • Cat. No. CS-0096856
  • Molecule weight208.44
  • Purity≥97%
  • MDL No.MFCD13189877

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloropyridin-4-ol|CS-0096856

Structure of 1196146-82-3

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General Information

  • CAS No. 1196146-82-3
  • Cat. No. CS-0096856
  • Purity ≥97%
  • MDL No. MFCD13189877
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrClNO
  • Molecular Weight 208.44
  • Synonym(s) 5-BroMo-2-chloro-4-hydroxypyridine
  • SMILES OC1=CC(Cl)=NC=C1Br

Description

5-Bromo-2-chloropyridin-4-ol features a pyridinol scaffold with bromo and chloro substituents at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. The hydroxyl group enhances solubility and provides a handle for derivatization, while the halogenated framework ensures compatibility with palladium-catalyzed transformations under standard conditions.

Application

5-Bromo-2-chloropyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group undergoes efficient Suzuki, Stille, or Negishi coupling, while the chloro and hydroxyl functionalities offer sites for further derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in the construction of functionalized heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.2031
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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