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2-Chloro-5-hydroxy-4-methylpyridine

  • CAS No. 1227502-89-7

  • Cat. No. CS-0195236
  • Molecule weight143.57
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-hydroxy-4-methylpyridine|CS-0195236

Structure of 1227502-89-7

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General Information

  • CAS No. 1227502-89-7
  • Cat. No. CS-0195236
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) 6-Chloro-4-methylpyridin-3-ol
  • SMILES CC1=CC(=NC=C1O)Cl

Description

2-Chloro-5-hydroxy-4-methylpyridine features a reactive chloro group flanked by a hydroxyl and methyl substituent on the pyridine ring, enabling selective functionalization in synthetic pathways. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds and serves as a key intermediate in agrochemical and pharmaceutical development under standard conditions.

Application

2-Chloro-5-hydroxy-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. The hydroxyl group facilitates direct derivatization or protection, while the chloro and methyl substituents provide orthogonal reactivity for cross-coupling and functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for modular synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.74902
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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