2-Chloro-4-iodo-6-methylpyridine

CAS No. 1227592-89-3
Cat. No. CS-0161372
Purity≥98%
MDL No.MFCD16610530

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-4-iodo-6-methylpyridine|CS-0161372

Structure of 1227592-89-3

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Description

2-Chloro-4-iodo-6-methylpyridine features a trifunctional pyridine core with complementary halogen handles, enabling sequential cross-coupling reactions. The chlorine and iodine substituents facilitate orthogonal reactivity in palladium-catalyzed transformations, while the methyl group enhances solubility and electronic modulation. This bench-stable derivative serves as a key building block for bioactive heterocycles and advanced pharmaceutical intermediates.

Application

2-Chloro-4-iodo-6-methylpyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its orthogonal halogen reactivity. The chloro group exhibits high stability under standard reaction conditions, while the iodo substituent facilitates rapid coupling with boronic acids and organometallics. Its methyl group provides a convenient handle for further functionalization, and the molecule demonstrates excellent bench stability and ease of purification—ideal for iterative synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

General Information

CAS No. 1227592-89-3
Cat. No. CS-0161372
Purity ≥98%
MDL No. MFCD16610530
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClIN
Molecular Weight 253.47
Synonym(s) 2-Chloro-4-iodo-6-methyl-pyridine
SMILES CC1=CC(I)=CC(Cl)=N1

Computational Chemistry Data

TPSA 12.89
LogP 2.64802
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-iodo-6-methylpyridine

CAS No. 1227592-89-3

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