6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine

CAS No. 1234616-70-6
Cat. No. CS-0139566
Purity≥97%
MDL No.None

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6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine|CS-0139566

Structure of 1234616-70-6

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Description

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine features a rigid heteroaromatic core with strategically positioned halogens enabling direct functionalization. The bromine at the 6-position facilitates palladium-catalyzed cross-coupling, while the 2,4-dichloro substitution provides orthogonal reactivity for sequential derivatization. This compound serves as a high-impact scaffold in kinase inhibitor development and advanced medicinal chemistry campaigns.

Application

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromine and two chloro groups provide orthogonal reactivity for sequential derivatization, while the pyridopyrimidine core offers structural rigidity and favorable electronic properties for target engagement. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for high-throughput synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 1234616-70-6
Cat. No. CS-0139566
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₂BrCl₂N₃
Molecular Weight 278.92
Synonym(s) 6-bromo-2,4-dichloro-pyrido[2,3-d]pyrimidine
SMILES ClC1=C(C=C(Br)C=N2)C2=NC(Cl)=N1

Computational Chemistry Data

TPSA 38.67
LogP 3.0941
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine

CAS No. 1234616-70-6

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