(R)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate

CAS No. 1240587-88-5
Cat. No. CS-0088872
Purity≥97%
MDL No.None

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(R)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate|CS-0088872

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Description

(R)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate is a bench-stable, moisture-tolerant chiral building block featuring a trifluoromethyl group that imparts strong electron-withdrawing character. This piperazine derivative integrates readily into medicinal chemistry campaigns, enabling access to complex nitrogen-containing scaffolds with enhanced metabolic stability and membrane permeability.

Application

(R)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of trifluoromethylated piperazine-containing scaffolds. Its tert-butyl carbamate group offers excellent bench stability and ease of removal under mild acidic conditions, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. The compound facilitates efficient functionalization at the piperazine nitrogen and supports diverse downstream transformations in API development.

General Information

CAS No. 1240587-88-5
Cat. No. CS-0088872
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₃N₂O₂
Molecular Weight 254.25
Synonym(s) tert-butyl (R)-3-(trifluoromethyl)piperazine-1-carboxylate
SMILES O=C(N1C[C@H](C(F)(F)F)NCC1)OC(C)(C)C

Computational Chemistry Data

TPSA 41.57
LogP 1.7576
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate

CAS No. 1240587-88-5

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