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CS-W001157 4
Total: USD 88.00

N-Desmethyl enzalutamide

  • CAS No. 1242137-16-1

  • Cat. No. CS-2992
  • Molecule weight450.41
  • Purity≥98%
  • MDL No.MFCD24386671

*For research and further manufacturing use only, not for direct human use.

N-Desmethyl enzalutamide|CS-2992

Structure of 1242137-16-1

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General Information

  • CAS No. 1242137-16-1
  • Cat. No. CS-2992
  • Purity ≥98%
  • MDL No. MFCD24386671
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₄F₄N₄O₂S
  • Molecular Weight 450.41
  • Synonym(s) N-Desmethyl MDV 3100
  • SMILES S=C(N1C2=CC(F)=C(C(N)=O)C=C2)N(C3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(C)1C)=O

Description

N-desmethyl Enzalutamide serves as a key metabolite of enzalutamide, retaining potent anti-androgenic activity. This compound features a desmethylated amine moiety that enhances metabolic stability and facilitates direct evaluation in pharmacokinetic studies. Its structural similarity to the parent drug enables use in comparative biological assays and mechanism-of-action investigations.

Application

N-Desmethyl Enzalutamide serves as a key synthetic intermediate in the development of androgen receptor antagonists, enabling straightforward access to enzalutamide analogs via late-stage functionalization. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient derivatization for medicinal chemistry exploration.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   90.43
  • LogP   3.73178
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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