5-Bromo-2-methylpyridin-4-ol

CAS No. 1258287-39-6
Cat. No. CS-0043012
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Description

5-Bromo-2-methylpyridin-4-ol features a bromine substituent at the 5-position and a methyl group at the 2-position, flanking a phenolic hydroxyl at the 4-position. This arrangement imparts enhanced reactivity in cross-coupling processes, enabling efficient incorporation into complex heterocyclic scaffolds under mild conditions. The molecule exhibits robust stability and solubility in polar aprotic solvents, facilitating use in synthetic workflows requiring precise functionalization.

Application

5-Bromo-2-methylpyridin-4-ol serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling direct functionalization via palladium-catalyzed cross-coupling reactions. The bromo group at the 5-position provides high reactivity in Suzuki, Stille, and Negishi couplings, while the hydroxyl and methyl groups offer orthogonal handles for further derivatization. Its bench-stable solid form facilitates handling and purification, making it ideal for scalable synthesis of pyridine-based pharmaceutical intermediates and agrochemical scaffolds.

General Information

CAS No. 1258287-39-6
Cat. No. CS-0043012
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆BrNO
Molecular Weight 188.02
Synonym(s) 5-Bromo-2-methyl-4-pyridinol
SMILES OC1=CC(C)=NC=C1Br

Computational Chemistry Data

TPSA 33.12
LogP 1.85812
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-2-methylpyridin-4-ol

CAS No. 1258287-39-6

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