6-Chloro-3-fluoro-2-methoxypyridine

CAS No. 1261473-36-2
Cat. No. CS-0468513
Molecule weight161.56
Purity≥98%
MDL No.None

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6-Chloro-3-fluoro-2-methoxypyridine|CS-0468513

Structure of 1261473-36-2

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General Information

CAS No. 1261473-36-2
Cat. No. CS-0468513
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFNO
Molecular Weight 161.56
Synonym(s) None
SMILES COC1=NC(Cl)=CC=C1F

Description

6-Chloro-3-fluoro-2-methoxypyridine features a trifunctional pyridine core with orthogonal reactivity, enabling selective coupling in late-stage diversification. The electron-deficient ring facilitates nucleophilic substitution, while the methoxy group enhances solubility and modulates electronic effects. This bench-stable scaffold integrates readily into complex heterocyclic architectures under standard conditions.

Application

6-Chloro-3-fluoro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling selective functionalization at the C6 position via palladium-catalyzed cross-coupling. The ortho-fluoro substituent facilitates nucleophilic aromatic substitution under mild conditions, while the methoxy group provides a handle for further derivatization. Bench-stable and compatible with standard reaction protocols, it supports efficient access to complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 22.12
LogP 1.8827
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-fluoro-2-methoxypyridine

CAS No. 1261473-36-2

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