8-Bromo-4-chloropyrido[4,3-d]pyrimidine

CAS No. 1269421-61-5
Cat. No. CS-0528764
Purity≥95%
MDL No.MFCD22200034

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8-Bromo-4-chloropyrido[4,3-d]pyrimidine|CS-0528764

Structure of 1269421-61-5

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Description

8-Bromo-4-chloropyrido[4,3-d]pyrimidine is a heterocyclic scaffold featuring bromo and chloro substituents at the 8- and 4-positions, respectively. This electron-deficient core enables efficient cross-coupling reactions and serves as a key building block in medicinal chemistry. The molecule exhibits excellent stability under standard conditions and facilitates direct functionalization at multiple sites.

Application

8-Bromo-4-chloropyrido[4,3-d]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of purine-like scaffolds. Its dual halogen substituents facilitate palladium-catalyzed cross-coupling reactions, including Suzuki and Buchwald-Hartwig transformations, with excellent functional group tolerance. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive molecules.

General Information

CAS No. 1269421-61-5
Cat. No. CS-0528764
Purity ≥95%
MDL No. MFCD22200034
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrClN₃
Molecular Weight 244.48
Synonym(s) None
SMILES ClC1=C(C=NC=C2Br)C2=NC=N1

Computational Chemistry Data

TPSA 38.67
LogP 2.4407
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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8-Bromo-4-chloropyrido[4,3-d]pyrimidine

CAS No. 1269421-61-5

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