2-Methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-2H-indazole-3-carboxamide Granisetron impurity

CAS No. 127472-42-8
Cat. No. CS-0534047
Molecule weight312.41
Purity≥98%
MDL No.None

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2-Methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-2H-indazole-3-carboxamide Granisetron impurity|CS-0534047

Structure of 127472-42-8

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General Information

CAS No. 127472-42-8
Cat. No. CS-0534047
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₄N₄O
Molecular Weight 312.41
Synonym(s) 2-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide
SMILES CN([C@@H](CCC1)C2)[C@H]1C[C@@H]2NC(C3=C4C(C=CC=C4)=NN3C)=O

Description

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.

Synthesis

Route1
- 34252-44-3
- ~%
- In-stock
  
  127472-42-8
References
- Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929
Route2
- 76272-41-8
- 181071-92-1
- ~%
- In-stock
  
  127472-42-8
References
- Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 50.16
LogP 2.3184
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

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2-Methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-2H-indazole-3-carboxamide Granisetron impurity

CAS No. 127472-42-8

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