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CS-W001157 4
Total: USD 88.00

Ethyl 2-chloro-2-(hydroxyimino)acetate

  • CAS No. 14337-43-0

  • Cat. No. CS-D1024
  • Molecule weight151.55
  • Purity≥97%
  • MDL No.MFCD00010209

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-chloro-2-(hydroxyimino)acetate|CS-D1024

Structure of 14337-43-0

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General Information

  • CAS No. 14337-43-0
  • Cat. No. CS-D1024
  • Purity ≥97%
  • MDL No. MFCD00010209
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆ClNO₃
  • Molecular Weight 151.55
  • Synonym(s) α-Chloroglyoxalic Acid Ethyl Ester Oxime
  • SMILES CCOC(/C(Cl)=N/O)=O

Description

Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:in the preparation of (+)-and ()-2-isoxazolinesin the synthesis of CIP-AS (), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic ()-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptorsto generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonateto prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines

Synthesis

  • Route1
    • null|null
      31767-14-3
    • ~%
    • In-stock
      Ethyl 2-chloro-2-(hydroxyimino)acetate|CS-D1024
      14337-43-0

    References

    • Journal of Organic Chemistry, , vol. 23, p. 1517
  • Route2
    • H-Gly-Oet|CS-0636597
      459-73-4
    • ~20%
    • In-stock
      Ethyl 2-chloro-2-(hydroxyimino)acetate|CS-D1024
      14337-43-0

    References

    • ADVINUS THERAPEUTICS PVT. LTD., Patent: WO2009/118759 A2, 2009 ; Location in patent: Page/Page column 113 ; WO 2009/118759 A2
  • Route3
    • null|null
      31767-15-4
    • ~95%
    • In-stock
      Ethyl 2-chloro-2-(hydroxyimino)acetate|CS-D1024
      14337-43-0

    References

    • Shionogi and Co., Ltd. Patent: US4190728 A1, 1980 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS08
Signal Word : Danger
UN#: 3335
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H318-H334-H335
Precautionary Statements : P261-P264-P271-P280-P284-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   58.89
  • LogP   0.576
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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