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Structure of 1450754-38-7
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This diazirine derivative features a butynyl group and a 2-iodoethyl substituent, enabling site-specific photoaffinity labeling. The strained three-membered ring facilitates efficient crosslinking upon UV irradiation, while the iodoethyl moiety supports facile conjugation in bioconjugation workflows.
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine serves as a versatile bifunctional photoreactive probe, enabling site-specific protein labeling via UV-induced formation of reactive nitrenes. The diazirine moiety reacts efficiently with C–H and N–H bonds upon irradiation, while the terminal alkyne and iodoethyl groups support orthogonal bioconjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAC) or nucleophilic substitution. This combination facilitates modular, stepwise conjugation strategies in chemical biology workflows.
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GHS No : GHS02,GHS05
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Signal Word : Danger
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UN#: 2924
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Class : 3,8
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Packing Group : Ⅱ
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Hazard Statements : H226-H314
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Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501
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Lot numbers can be found on the outside label of a product: