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CS-W001157 4
Total: USD 88.00

3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

  • CAS No. 1450754-38-7

  • Cat. No. CS-0137485
  • Purity≥97%
  • MDL No.MFCD29918289
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine|CS-0137485

Structure of 1450754-38-7

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Description

This diazirine derivative features a butynyl group and a 2-iodoethyl substituent, enabling site-specific photoaffinity labeling. The strained three-membered ring facilitates efficient crosslinking upon UV irradiation, while the iodoethyl moiety supports facile conjugation in bioconjugation workflows.

Application

3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine serves as a versatile bifunctional photoreactive probe, enabling site-specific protein labeling via UV-induced formation of reactive nitrenes. The diazirine moiety reacts efficiently with C–H and N–H bonds upon irradiation, while the terminal alkyne and iodoethyl groups support orthogonal bioconjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAC) or nucleophilic substitution. This combination facilitates modular, stepwise conjugation strategies in chemical biology workflows.

General Information

  • CAS No. 1450754-38-7
  • Cat. No. CS-0137485
  • Purity ≥97%
  • MDL No. MFCD29918289
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉IN₂
  • Molecular Weight 248.06
  • Synonym(s) None
  • SMILES ICCC1(CCC#C)N=N1

Computational Chemistry Data

  • TPSA   24.72
  • LogP   2.387
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group :
Hazard Statements : H226-H314
Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501

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