4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

CAS No. 148256-82-0
Cat. No. CS-0050941
Purity≥98%
MDL No.None

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4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde|CS-0050941

Structure of 148256-82-0

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Description

4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde features a pyrimidine core bearing a chloro group, a methylthio substituent, and a formyl function at the 5-position. This electron-deficient scaffold integrates readily into heterocyclic syntheses, offering high reactivity in nucleophilic addition and coupling processes. The aldehyde functionality enables direct conjugation with amines or hydrazines under mild conditions. Bench-stable and moisture-tolerant, it serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. The aldehyde group facilitates nucleophilic additions and condensation reactions, while the chloro and methylthio substituents offer orthogonal reactivity for downstream functionalization. Bench-stable and compatible with standard purification methods, it functions effectively in coupling and heterocycle-forming processes common to API development.

General Information

CAS No. 148256-82-0
Cat. No. CS-0050941
Purity ≥98%
MDL No. None
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₂OS
Molecular Weight 188.63
Synonym(s) 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde
SMILES CSC1=NC=C(C=O)C(Cl)=N1

Computational Chemistry Data

TPSA 42.85
LogP 1.6644
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

CAS No. 148256-82-0

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