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Structure of 149709-44-4
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Sacubitrilat is a potent, orally bioavailable angiotensin receptor-neprilysin inhibitor that integrates dual-acting pharmacophores to modulate the renin-angiotensin and natriuretic peptide systems. This active metabolite features enhanced stability and targeted tissue distribution, enabling sustained inhibition of neprilysin and blockade of AT1 receptors. Designed for cardiovascular therapeutics, it supports improved hemodynamic profiles in heart failure with reduced ejection fraction.
Sacubitrilat serves as a potent, metabolically stable neprilysin inhibitor scaffold, enabling targeted modulation of natriuretic peptide signaling. Its carboxylic acid functionality facilitates direct interaction with the enzyme’s active site, while its aromatic core provides structural rigidity and favorable pharmacokinetic properties. The compound functions as a key intermediate in the synthesis of angiotensin receptor-neprilysin inhibitor (ARNI) therapeutics, offering consistent reactivity and purification advantages in multi-step organic syntheses.
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GHS No : GHS07,GHS08
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H336-H372
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Precautionary Statements : P260-P261-P264-P270-P271-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: