Fmoc-L-Lys(Dde)-OH

CAS No. 150629-67-7
Cat. No. CS-W022727
Purity≥97%
MDL No.MFCD00278818

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-L-Lys(Dde)-OH serves as a protected lysine derivative for solid-phase peptide synthesis, featuring a Dde (1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl) group that enables selective deprotection under mild conditions. This orthogonal protection strategy facilitates the incorporation of multiple functional side chains in complex peptide architectures. The Fmoc moiety ensures efficient N-terminal capping during chain elongation.

Application

Fmoc-L-Lys(Dde)-OH serves as a key building block in solid-phase peptide synthesis, enabling orthogonal side-chain protection for lysine residues. The Fmoc group facilitates efficient N-terminal deprotection under mild basic conditions, while the Dde (2,4-dimethoxybenzyl) protecting group on the ε-amino function is selectively removable via hydrazinolysis, allowing sequential coupling and modification in complex peptide architectures. Its bench-stable nature and compatibility with standard SPPS workflows make it ideal for synthesizing multi-functionalized peptides and peptidomimetics.

General Information

CAS No. 150629-67-7
Cat. No. CS-W022727
Purity ≥97%
MDL No. MFCD00278818
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₁H₃₆N₂O₆
Molecular Weight 532.63
Synonym(s) None
SMILES O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCCCNC(C)=C4C(CC(C)(C)CC4=O)=O

Computational Chemistry Data

TPSA 121.8
LogP 4.9704
H_Acceptors 6
H_Donors 3
Rotatable_Bonds 10

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Lysine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

Key Words

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Fmoc-L-Lys(Dde)-OH

CAS No. 150629-67-7

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