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CS-W001157 4
Total: USD 88.00

5-Chloro-3-methyl-1H-pyrazole

  • CAS No. 15953-45-4

  • Cat. No. CS-0050525
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-methyl-1H-pyrazole|CS-0050525

Structure of 15953-45-4

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Description

5-Chloro-3-methyl-1H-pyrazole is a bench-stable heterocyclic scaffold featuring a chlorinated pyrazole core with a methyl substituent at the 3-position. This electron-deficient ring system integrates readily into medicinal chemistry libraries, offering enhanced metabolic stability and enabling direct coupling in cross-coupling reactions.

Application

5-Chloro-3-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrazole scaffolds via cross-coupling and nucleophilic substitution reactions. Its chlorine at C5 provides a reliable handle for palladium-catalyzed functionalization, while the methyl group at C3 enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse reaction conditions, making it ideal for high-throughput synthesis of bioactive heterocycles.

General Information

  • CAS No. 15953-45-4
  • Cat. No. CS-0050525
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClN₂
  • Molecular Weight 116.55
  • Synonym(s) 5-Chloro-3-methylpyrazole
  • SMILES CC1=NNC(Cl)=C1

Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.37152
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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