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Structure of 162012-69-3
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7-Fluoro-6-nitroquinazolin-4(3H)-one features a fluorinated quinazolinone core with strategic electron-withdrawing nitro and fluoro substituents, enhancing its utility in medicinal chemistry. This scaffold exhibits high reactivity in nucleophilic substitution reactions and serves as a key intermediate for bioactive heterocycles. The compound demonstrates stability under standard bench conditions and compatibility with diverse synthetic transformations.
7-Fluoro-6-nitroquinazolin-4(3H)-one serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling direct functionalization at the C4 position via nucleophilic substitution or reduction. Its electron-deficient quinazoline core enhances reactivity in coupling processes, while the fluorine and nitro groups provide orthogonal handles for downstream derivatization. Bench-stable and amenable to purification by recrystallization, it functions effectively in standard synthetic workflows targeting kinase inhibitors and other bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: