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CS-W001157 4
Total: USD 88.00

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine Trimethoprim Impurity

  • CAS No. 16285-82-8

  • Cat. No. CS-0531859
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine Trimethoprim Impurity|CS-0531859

Structure of 16285-82-8

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Description

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine serves as a critical impurity reference standard in the synthesis and quality control of trimethoprim. This compound features a brominated dimethoxybenzyl substituent attached to a pyrimidine-2,4-diamine core, exhibiting enhanced stability under standard handling conditions. Its well-defined structure enables accurate detection and quantification in pharmaceutical development workflows.

Application

5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine serves as a well-characterized impurity in trimethoprim synthesis, enabling accurate method development and quality control in pharmaceutical assays. Its stable pyrimidine core with orthogonal diamine and brominated benzyl functionalities facilitates targeted derivatization and chromatographic monitoring. The compound exhibits predictable reactivity in standard coupling and purification workflows, supporting its use in reference material preparation and process analytical testing.

General Information

  • CAS No. 16285-82-8
  • Cat. No. CS-0531859
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅BrN₄O₂
  • Molecular Weight 339.19
  • Synonym(s) Trimethoprim impurity F
  • SMILES BrC1=C(OC)C(OC)=CC(CC2=CN=C(N)N=C2N)=C1

Computational Chemistry Data

  • TPSA   96.28
  • LogP   2.0115
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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