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CS-W001157 4
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10-(3-(4-(2-Hydroxyethyl)piperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine 5-oxide Fludarabine Impurity

  • CAS No. 1674-76-6

  • Cat. No. CS-0534046
  • Molecule weight453.52
  • Purity≥98%
  • MDL No.MFCD22666247

*For research and further manufacturing use only, not for direct human use.

10-(3-(4-(2-Hydroxyethyl)piperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine 5-oxide Fludarabine Impurity|CS-0534046

Structure of 1674-76-6

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General Information

  • CAS No. 1674-76-6
  • Cat. No. CS-0534046
  • Purity ≥98%
  • MDL No. MFCD22666247
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₆F₃N₃O₂S
  • Molecular Weight 453.52
  • Synonym(s) Fluphenazine sulfoxide
  • SMILES O=S1C=2C=CC=CC2N(C3=CC(=CC=C31)C(F)(F)F)CCCN4CCN(CCO)CC4

Description

A bioavailable, moderately toxic, deoxyctytidine analog with anti-metabolite and anti-tumor properties. Shown to be effective against a variety of tumors and blocks the growth of cancer cells in culture (IC 50 = 8.7, 57, 3.7, and 36 nM for L1210, CEM, Caco2, and HeLa cells, respectively). Following its uptake into cells by nucleoside transporters it is phosphorylated to its mono (dFdCMP), di (dFdCDP), and triphosphorylated (dFdCTP) forms by deoxycytidine kinase. dFdCDP and dFdCTP are reported to inhibit the activity of ribonucleotide reductase and impede DNA synthesis and repair mechanisms and induce cell death. Blocks the progression of cells through the G1/S phase. The dFdCTP is shown to compete with endogenous deoxycytidine triphosphate (dCTP) for incorporation into DNA and against CTP into RNA. Gemcitabine is also shown to block mitochondrial DNA polymerase . Works synergistically with other chemotherapeutic agents to enhance their cytotoxicity. Its half life is reported to be 42 to 94 min (depending upon the age and sex of the individual).

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   47.02
  • LogP   3.3236
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   6

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