1-Bromo-3,5-difluoro-2-iodobenzene

CAS No. 175278-11-2
Cat. No. CS-W012012
Purity≥98%
MDL No.MFCD00042183

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Bromo-3,5-difluoro-2-iodobenzene|CS-W012012

Structure of 175278-11-2

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Description

1-Bromo-3,5-difluoro-2-iodobenzene features a uniquely activated aromatic core bearing strategically positioned halogens: bromine at C1, fluorine at C3 and C5, and iodine at C2. This electronic asymmetry enables selective cross-coupling transformations under palladium catalysis. The molecule exhibits excellent stability under standard bench conditions and facilitates efficient diversification in complex heterocycle synthesis.

Application

1-Bromo-3,5-difluoro-2-iodobenzene serves as a versatile diaryl building block for palladium-catalyzed cross-coupling reactions. The orthogonal reactivity of bromo and iodo groups enables sequential functionalization, while the electron-withdrawing difluoro substituents enhance stability and modulate electrophilicity. This compound facilitates efficient access to substituted biaryls and heterocyclic scaffolds relevant to medicinal chemistry and materials science, offering predictable regiochemistry and robust performance in standard coupling protocols.

General Information

CAS No. 175278-11-2
Cat. No. CS-W012012
Purity ≥98%
MDL No. MFCD00042183
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrF₂I
Molecular Weight 318.89
Synonym(s) 6-bromo-2,4-difluoro-iodobenzene
SMILES FC1=CC(Br)=C(I)C(F)=C1

Computational Chemistry Data

TPSA 0
LogP 3.3319
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-3,5-difluoro-2-iodobenzene

CAS No. 175278-11-2

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