7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline

CAS No. 1783624-20-3
Cat. No. CS-0142919
Purity≥97%
MDL No.None

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline|CS-0142919

Structure of 1783624-20-3

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Description

7-(Difluoromethyl)-1,2,3,4-tetrahydroquinoline is a fluorinated heterocyclic scaffold featuring a difluoromethyl group at the 7-position, enhancing metabolic stability and modulating electronic properties. This bench-stable compound integrates readily into medicinal chemistry campaigns targeting CNS agents and kinase inhibitors, offering improved lipophilicity and bioavailability over non-fluorinated analogs.

Application

7-(Difluoromethyl)-1,2,3,4-tetrahydroquinoline serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group at the quinoline C7 position. The difluoromethyl moiety offers enhanced metabolic stability and modulated lipophilicity, while the tetrahydroquinoline core provides a rigid, bioactive scaffold suitable for target-directed synthesis. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization in multi-step syntheses.

General Information

CAS No. 1783624-20-3
Cat. No. CS-0142919
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁F₂N
Molecular Weight 183.20
Synonym(s) 7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline(WXC01614)
SMILES FC(C1=CC2=C(C=C1)CCCN2)F

Computational Chemistry Data

TPSA 12.03
LogP 2.9823
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1760
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroquinoline compounds

Key Words

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7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline

CAS No. 1783624-20-3

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