Lot numbers can be found on the outside label of a product:
7,10-Dimethoxy-10-DAB III
-
CAS No. 183133-94-0
- Cat. No. CS-0022604
- Purity≥98%
- MDL No.MFCD23100710
*For research and further manufacturing use only, not for direct human use.
Structure of 183133-94-0
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 183133-94-0
- Cat. No. CS-0022604
- Purity ≥98%
- MDL No. MFCD23100710
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₃₁H₄₀O₁₀
- Molecular Weight 572.64
- Synonym(s) 10-Deacetyl-7,10-dimethylbaccatin III; (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
- SMILES CC(O[C@]12[C@@]([C@]3([C@@H](OC)C[C@@]1([H])OC2)C)([H])[C@@H]([C@]4(C(C)(C([C@@H](OC)C3=O)=C(C)[C@@H](O)C4)C)O)OC(C5=CC=CC=C5)=O)=O
Description
7,10-Dimethoxy-10-DAB III features a rigid tetracyclic core with strategically positioned methoxy groups that enhance solubility and metabolic stability. This derivative serves as a key intermediate in the synthesis of complex natural products, offering improved handling properties and compatibility with late-stage functionalization under mild conditions.
Application
7,10-Dimethoxy-10-deacetylbaccatin III serves as a key advanced intermediate in the synthesis of taxane-based pharmaceuticals. Its well-defined functionalization enables efficient derivatization at C10 and C7 positions, facilitating scalable semi-synthesis of paclitaxel and related analogs. The dimethoxy substitution enhances stability and solubility, supporting robust handling and purification in multi-step workflows.
Synthesis
-
Route1
-
709673-79-0 - ~59%
-
In-stock
183133-94-0
References
-
PLUS CHEMICALS SA; TEVA PHARMACEUTICALS USA, INC.; SIMO, Ondrej; VRASPIR, Pavel; HOLAS, Tomas; JEGOROV, Alexandr; GABRIEL, Roman Patent: WO2012/142117 A1, 2012 ; Location in patent: Page/Page column 33 ;
-
-
Route2
-
183133-97-3
-
74-88-4
- ~61%
-
In-stock
183133-94-0
References
-
ScinoPharm Taiwan Ltd.; Hsiao, TsungYu; Tseng, HsinChang Patent: US2013/90484 A1, 2013 ; Location in patent: Paragraph 0046-0047 ;
-
-
Route3
-
1432613-35-8
- ~42%
-
In-stock
183133-94-0
References
-
Scinopharm Taiwan, LTD.; Hsiao, TsungYu; Henschke, Julian Paul; Tseng, HsinChang Patent: US2013/116444 A1, 2013 ; Location in patent: Paragraph 0167 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302
|
|
|
Precautionary Statements : P264-P270-P330-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 137.82
- LogP 2.39
- H_Acceptors 10
- H_Donors 2
- Rotatable_Bonds 5
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 7,10-Dimethoxy-10-DAB III sigma7,10-Dimethoxy-10-DAB III manufacturer7,10-Dimethoxy-10-DAB III price7,10-Dimethoxy-10-DAB III structure7,10-Dimethoxy-10-DAB III SDSbuy 7,10-Dimethoxy-10-DAB III7,10-Dimethoxy-10-DAB III supplier7,10-Dimethoxy-10-DAB III uses7,10-Dimethoxy-10-DAB III molecular weightprice of 7,10-Dimethoxy-10-DAB III7,10-Dimethoxy-10-DAB III chemical name formula of 7,10-Dimethoxy-10-DAB III